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Co-administration of ketoconazolean inhibitor of CYP3A4 with cilostazol resulted in a 117increase in the AUC of cilostazolaccompanied by a 15decrease in the AUC of the dehydro metabolite and a 87increase in the AUC of the 4trans-hydroxy metaboliteBased on AUCthe overall pharmacological activity of cilostazol increases 35when co-administered with ketoconazoleBased on these datathe recommended dose of cilostazol is 50 mg bid in the presence of ketoconazole and similar agentse.gitraconazole
Headachediarrhearunny noseand dizziness may occurIf any of these effects persist or worsentell your doctor or pharmacist promptly.
The effect of CYP3A4 and CYP2C19 inducerssuch as carbamazepinephenytoinrifampicin and StJohn’s worton cilostazol pharmacokinetics has not been evaluatedThe antiplatelet effect may theoretically be altered and should be carefully monitored when cilostazol is co-administered with CYP3A4 and CYP2C19 inducers.
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