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31Yodaiken REBennett DOSHA Work-Practice guidelines for personnel dealing with cytotoxicantineoplasticdrugsAm J Hosp Pharm199643:1193-1204.
8Black AJMcLeod HLCapell HAet alThiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprineAnn Intern Med1998129:716-718.
Azathioprine is principally excreted as 6-thiouric uric acid in the urine1-methyl-4-nitro-5-thioimidazole has also been detected in urine as a minor excretory productThis would indicate thatrather than azathioprine being exclusive cleaved by nucleophilic attack at the 5-position of the nitroimidazole ring to generate 6-MP and 1-methyl-4-nitro-5S-glutathionyl)imidazoleA small proportion of the drug may be cleaved between the buy medication from india. S atom and the purine ringOnly a small amount of the dose of azathioprine administered is excreted unmetabolised in the urine.
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