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Dapoxetine undergoes rapid absorption and elimination resulting in minimal accumulation and has dose-proportional pharmacokineticswhich are unaffected by multiple dosing and do not vary between ethnic groupsFigure 2Dresser et al2006bDresser et al2004Modi et al2006The pharmacokinetic profile of dapoxetine suggests that it is a good candidate for on-demand treatment of PE.

Sildenafil has also been shown to induce a state of peripheral analgesia via valium generico india. activation of the NO/cGMP signaling pathway in animalsJain et al 2001This effect could be instrumental in alleviating the penile hypersensivity that is reported in some patients with PE and may in turn mimic the success of topical anesthetics in the treatment of some PE patientsBerkovitch et al 1995

In a recent Sexual Medicine studyalmost 80of men stopped using dapoxetine within the first six monthsCost was the most commonly-cited reason.

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