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Thiazide diuretics such as hydrochlorothiazide hydrodiuril may increase glucose concentration in the blood and reduce effects of micronase.

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Thiazide diureticsfor examplehydrochlorothiazideHydrodiurilincrease blood glucose levelsreducing the effect of glucose reducing medications such as glyburide.

All medicines may cause side effectsbut many people have noor minorside effectsCheck with your doctor if any of these most COMMON side effects persist or become bothersome:

Because recent information suggests that abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital abnormalitiesmany experts recommend that insulin be used during pregnancy to maintain blood glucose as close to normal as possible.

Single dose studies with MICRONASE Tablets in normal subjects demonstrate significant absorption of glyburide within one hourpeak drug levels at about four hoursand low but detectable levels at twenty-four hoursMean serum levels of glyburideas reflected by areas under the serum concentration-time curveincrease in proportion to corresponding increases in doseMultiple dose studies with MICRONASE in diabetic patients demonstrate drug level concentration-time curves similar to single dose studiesindicating no buildup of drug in tissue depotsThe decrease of glyburide in the serum of normal healthy individuals is biphasicthe terminal half-life is about 10 hoursIn single dose studies in fasting normal subjectsthe degree and duration of blood glucose lowering is proportional to the dose administered and to the area under the drug level concentrationtime curveThe blood glucose lowering effect persists for 24 hours following single morning doses in nonfasting diabetic patientsUnder conditions of repeated administration in diabetic patientshoweverthere is no reliable correlation between blood drug levels and fasting blood glucose levelsA one year study of diabetic patients treated with MICRONASE showed no reliable correlation between administered dose and serum drug level.

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